Adults: For both hypertension and angina, the recommended initial dose is 5 mg Amlodipine orally once daily which may be increased to a maximum dose of 10 mg depending on the individual patient's response. The dose does not need adjusting when Amlodipine is given concurrently with thiazide diuretics, beta-adrenoreceptor blocking agents or angiotensin-converting enzyme inhibitors (ACEIs). Amlodipine can be administered with or without food. Use in children: Since there is no clinical experience in patients of less than 18 years, use in children is not currently recommended. Use in the elderly: Although elderly patients may have higher plasma concentration of Amlodipine than younger patients, the terminal elimination half-lives are similar. Amlodipine is similarly well tolerated in elderly or younger patients. Therefore the normal dose is recommended. Use with renal impairment: Changes in Amlodipine plasma concentration are not correlated with degree of renal impairment, therefore the normal dosage is recommended. Amlodipine is not dialyzable. Use in patients with impaired hepatic function: The half live of Amlodipine in patients with impaired liver function and dosage recommendation have not been established. Amlodipine should therefore be administered with caution in these patients.

Amlodipine is contraindicated in patients with known hypersensitivity to Amlodipine. Increased angina and/or myocardial infarction: Rarely, patients, particularly those with severe obstructive coronary artery disease, have developed documented increased frequently, duration and/or severity of angina or acute myocardial infarction on starting calcium channel blocker therapy or at the time of dosage increase. The mechanism of this effect has not been elucidated. Use in Pregnancy & Lactation: Safety of Amlodipine in human pregnancy and lactation has not been established. Therefore, Amlodipine should not be administered during pregnancy, or lactation, or to women of child bearing potential unless effective contraception is used.

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