DOSAGE AND ADMINISTRATION: Hypertension- Adults Dosage must be individualized. Response is dose related over the range of 2 to 32 mg. The usual recommended starting dose of ADVANT(Candesartan cilexetil) is 8 mg once daily when it is used as mono-therapy in patients who are not volume depleted. ADVANT (Candesartan cilexetil) can be administered once or twice daily with total daily doses ranging from 8 mg to 32 mg. Most of the antihypertensive effect is present within 2 weeks and maximal blood pressure reduction is generally obtained within 4 to 6weeks of treatment with ADVANT( Candesartan cilexetil ). ADVANT (Candesartan cilexetil) may be administered with or without food. Pediatrics: ADVANT (Candesartan cilexetil) may be administered once daily or divided into two equal doses. Adjust the dosage according to blood pressure response. For patients with possible depletion of intravascular volume (e.g.,patients treated with diuretics, particularly those with impaired renal function) ,initiate ADVANT (Candesartan cilexetil) under close medical supervision and consider administration of a lower dose. Children 1 to <6 years of age: The dose range is 0.05 to 0.4 mg/kg per day. The recommended starting dose is 0.20 mg/kg. Children 6 to <17 years of age: For those less than 50 kg, the dose range is 2 to 16 mg per day. The recommended starting dose is 4 to 8 mg. For those greater than 50 kg, the dose range is 4 to 32 mg per day. The recommended starting dose is 8 to 16 mg. An antihypertensive effect is usually present within 2 weeks, with full effect generally obtained within 4 weeks of treatment with ADVANT (Candesartan cilexetil). Children < 1 year of age must not receive ADVANT (Candesartan cilexetil) for hypertension. Heart Failure: The recommended initial dose for treating heart failure is 4 mg once daily. The target dose is 32 mg once daily, which is achieved by doubling thedose at approximately 2-week intervals, as tolerated by the patient.

CONTRAINDICATIONS:Candesartan cilexetil is contraindicated in patients who are hypersensitive to this drug or any component of this product. WARNINGS / PRECAUTIONS:General -As with any antihypertensive agent, excessive blood pressure decrease in patients with ischaemic cardiopathy or ischaemic cerebrovascular disease could result in a myocardial infarction or stroke.