Method of administration: CoAprovel is for oral use. Swallow the tablets with a sufficient amount of fluid (e.g. one glass of water). You can take CoAprovel with or without food. Try to take your daily dose at about the same time each day. It is important that you continue to take CoAprovel until your doctor tells you otherwise. The maximal blood pressure lowering effect should be reached 6-8 weeks after beginning treatment. Dosage: The recommended dose of CoAprovel is one or two tablets a day. CoAprovel will usually be prescribed by your doctor when your previous treatment did not reduce your blood pressure enough. Your doctor will instruct you how to switch from the previous treatment to CoAprovel.

Do not take CoAprovel: • if you are allergic to irbesartan or any of the other ingredients of this medicine.• if you are allergic to hydrochlorothiazide or any other sulfonamide-derived medicines. • if you are more than 3 months pregnant. (It is also better to avoid CoAprovel in early pregnancy).• if you have severe liver or kidney problems.• if you have difficulty in producing urine.• if your doctor determines that you have persistently high calcium or low potassium levels in your blood.• if you have diabetes or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren.

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